Table 2. Number of genes subjected to GAN reconstruction and properties of resulted GANs.
method | NCSRM | BETR | ||||||
---|---|---|---|---|---|---|---|---|
cell line and applied radiation dose | Increased sensitivity (1 Gy) | normal sensitivity (1 Gy) | Increased sensitivity (10 Gy) | normal sensitivity (10 Gy) | Increased sensitivity (1 Gy) | normal sensitivity (1 Gy) | Increased sensitivity (10 Gy) | normal sensitivity (10 Gy) |
number of genes taken for network reconstruction | 2335 | 7 | 6019 | 3892 | 923 | 12 | 3889 | 1256 |
number of nodes remained in the network | 1140 | - | 3483 | 2735 | 336 | - | 2299 | 773 |
number of edges in the network | 12198 | - | 114629 | 84695 | 3268 | - | 126378 | 16862 |
network density | 0.00939 | - | 0.00945 | 0.01133 | 0.02903 | - | 0.02392 | 0.02826 |
density of the Reactome interaction network | 0.00536 |
Gene association network reconstructions were performed using the GeneNet method [18]. Association between two genes was considered as significant if posterior edge probability was equal or greater than 0.95. Densities of the reconstructed networks were compared with the density of the Reactome interaction network in order to assess their complexity.