Skip to main content
. 2016 Aug 9;10(8):e0004911. doi: 10.1371/journal.pntd.0004911

Fig 2. Inflammation of the skin infection site in the absence of IL-4Rα and RELMα following 4x schistosome infection.

Fig 2

A. Pinnae thickness in naïve, 1x and 4x infected WT and IL-4RαKO mice and, B. in naïve, 1x and 4x infected WT and RelmαKO mice on day 4 after the final infection. Symbols are values for individual mice; horizontal bars are means ±SEM (n = 4–5 mice). C-H. Production of IL-4, IL-12p40 and IL-10 by skin biopsies (cultured in the absence of exogenous parasite antigen) from groups of WT, IL-4RαKO and RelmαKO mice. Cytokine production in the overnight culture supernatants was determined by ELISA (pg/ml); n = 4–5 mice per group. * = p<0.05; ** = p<0.01; *** = p<0.001, **** = p<0.0001, n.s. = p>0.05 as determined by ANOVA and Tukey’s post test analysis.