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. 2016 Aug 9;11(8):e0160840. doi: 10.1371/journal.pone.0160840

Fig 5. Gut microbiota determines severity of myocardial infarction.

Fig 5

A. Antibiotics added to the drinking water reduced infarct size (IS) in vivo. B. Antibiotics added directly to the coronary circulation of isolated hearts did not reduce IS in vitro. C. Antibiotics added to the drinking water and then excluded from the coronary circulation of isolated hearts reduced IS. Data are means ± SD; n = 6/group. AAR, area at risk. LV, left ventricle. Reduction in infarct size was similar for in vitro and in vivo studies (A, C). *P < 0.01 vs. control. Representative images of rat heart slices for measurement of infarct size are shown in the Supporting Information (S1 Fig).