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. Author manuscript; available in PMC: 2016 Aug 9.
Published in final edited form as: Nature. 2015 Jan 8;517(7533):165–169. doi: 10.1038/nature13995

Fig. 5. Model of HMNG depolymerisation by Bt.

Fig. 5

The interaction of mannose with the surface glycan binding protein (SGBP) is shown, while the binding of the SusD homolog (D) to the reducing end GlcNAc directs the N-glycan into the SusC-like (C) porin. In both the yeast mannan and the HMNG models the bulk of glycan degradation occurs in the periplasm (P) and not on the surface. The likely enzymes involved in the periplasmic degradation of the trisaccharide generated by the HMNG-PUL encoded system is addressed in Supplementary Information Section 4.3.