Table 1. Characterization of patients at baseline.

Variables	Control n = 14	IgM-IVIg n = 12	p-value*
Age [median (IQR)]	70 (63/76)	73 (67/77)	0.959
Male [n (%)]	10 (71.4)	8 (66.7)	0.67
BMI [median (IQR)]	31.8 (27.5/37)	26.5 (23.5/29.5)	0.015
APACHE II [median (IQR)]	35 (30/41)	35 (31/38)	0.69
Source of infection	Lung n = 5	Lung n = 3
	Abdominal n = 5	Abdominal n = 4
	Positive Blood Culture n = 2	Positive Blood Culture n = 1
	Other n = 1	Other n = 2
	No Pathogen n = 1	No Pathogen n = 2
Diabetes [n (%)]	5 (35.7)	0 (0)	0.03
Arterial Hypertension [n (%)]	8 (57.1)	8 (66.7)	0.464
Cardiovascular Disease [n (%)]	4 (28.6)	7 (58.3)	0.128
Renal Insufficiency [n (%)]	9 (64.3)	2 (16.7)	0.019
Hepatic Insufficiency [n (%)]	3 (21.4)	1 (8.3)	0.359
COPD [n (%)]	4 (28.6)	1 (8.3)	0.213
Nicotine Abuse [n (%)]	3 (21.4)	1 (8.3)	0.359
Immunosuppression [n (%)]	1 (7.1)	0 (0)	0.538

BMI, body mass index; APACHE II, Acute Physiology And Chronic Health Evaluation II; COPD, Chronic Obstructive Pulmonary Disease; IQR, interquartile range; IgM-IVIg, IgM-enriched intravenous immunoglobulin

* p-values were calculated using the Fisher exact test, Student’s t-test or the Mann-Whitney-test as appropriate, values <0.05 were considered statistically significant