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. Author manuscript; available in PMC: 2016 Aug 9.
Published in final edited form as: Nat Med. 2014 May 11;20(6):664–669. doi: 10.1038/nm.3549

Figure 4.

Figure 4

PDX therapy improves insulin sensitivity in diabetic mice. (a) Pre-clamp glycemia (left) and clamp glucose excursion (right), (b) glucose infusion rate (GIR) (left) and mean GIR for the final 60 min of clamp (right) in vehicle (veh) and acute PDX-treated genetically obese diabetic db/db mice. (c) Relative mRNA expression of Ppargc1, Pck1 and G6Pc normalized to GAPDH in liver from clamped veh and acute PDX-treated db/db mice. (d) Chemokines and cytokines in epididymal white adipose tissue (eWAT) of clamped veh and acute PDX-treated db/db mice. (e) Skeletal muscle (left) and plasma (right) IL-6 content from of clamped veh and acute PDX-treated db/db mice. Data are mean ± s.e.m. Veh n = 3, PDX n = 4, * P<0.05, **P<0.01 calculated using Student’s t-test.