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Schematic of cases with aberrations in the DNA repair pathway in metastatic castration-resistant prostate cancer [3]. Mutations in DNA repair genes were seen in 22.7% of cases. The majority of mutations were found in BRCA2 and ATM, but mutations were also observed in BRCA1, FANCA, RAD51B, RAD51C, and the mismatch repair genes MLH1 and MSH2.
