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. 2016 Aug 10;10:60. doi: 10.3389/fncir.2016.00060

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Copyright © 2016 Matynia, Nguyen, Sun, Blixt, Parikh, Kessler, Pérez de Sevilla Müller, Habib, Kim, Wang, Rodriguez, Charles, Nusinowitz, Edvinsson, Barnes, Brecha and Gorin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Latent light detection after ONC is revealed by administration of NTG. Light aversion was tested pre-injection (white) and post-injection (black) of 10 mg/kg NTG. (A) OPN4^+/+ wild type mice with sham surgery (n = 8, T₁₄ = 3.3, p = 0.005) and ONC (n = 8, T₁₄ = 2.8, p = 0.01) show increased light aversion with NTG. (B) OPN4^dta/dta mice with sham surgery (n = 8, T₁₄ = 3.8, p = 0.002) show increased light aversion with NTG whereas OPN4^dta/dta mice with ONC (n = 8, T₁₄ = 0.5, p = 0.6) show no increase in light aversion. Data are represented as mean ± SEM, Students t-test and p-values are given. ^* p < 0.05.