Table 2.
AQP1-WT Normoxia (N = 8) | AQP1-KO Normoxia (N = 6) | AQP1-WT Hypoxia (N = 9) | AQP1-KO Hypoxia (N = 7) | |
---|---|---|---|---|
SO2,a (%) [at O2,max] | 96.8 ± 1.1 | 96.9 ± 1.1ns | 64.2 ± 3.1 | 65.5 ± 2.2ns |
HR (min−1) [at O2,max] | 770 ± 7 | 717 ± 28ns | 736 ± 11 | 677 ± 31ns |
RR (min−1) [at O2, max] | 192 ± 13 | 168 ± 10ns | 197 ± 13 | 183 ± 20ns |
SO2, a arterial oxygen saturation (taken above the carotid artery), HR heart rate, RR respiratory rate. All measurements were obtained in about the same time interval as the O2, max measurements, a few minutes after the start of exposure to a helium mixture (21% O2, 79% He in normoxia, 11% O2, 10% N2, 79% He in hypoxia). Given are means ± SD. Statistical significances refer to comparisons of pairs of sets of KO- vs. WT-values (unpaired t-test). Levels of significance are from top down 0.92, 0.12, and 0.17 (3rd vs. 2nd column) and 0.73, 0.11 and 0.58 (5th vs. 4th column). Mean body weights were between 25 and 31 g.