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Pseudosynaptic stimuli evoked irregular firing in an example neuron. The mean inter-EPSC interval was fixed at 1 ms. To drive spiking at different rates, the neuron was stimulated with EPSCs whose average amplitude ranged from 0.01 to 3 (relative to a nominal amplitude of 150 pA; i.e., corresponding to EPSCs ranging from 1.5 to 450 pA). Periods of nonspiking, depolarization block, and burst spiking were detected at the highest stimulus amplitudes.
