Figure 4.

β-catenin knockdown increased sensitivity to cisplatin in vivo. (a) Photographs of tumors (A: OX-NC, B: OX, C: LX-NC, and D: LX). (b) Tumor sizes were measured from day 14 until mice were killed. When tumor volumes reached 100 to 150 mm³, mice were injected with 4 mg/kg cisplatin through the tail vein. (c) Tumor weight was measured at the end of the experiment. The tumor weight was significantly reduced in mice treated with OSCC cells with β-catenin knockdown after cisplatin treatment, whereas the tumor size continuously increased with the overexpression of β-catenin indicating promoted tumor growth. ^∗ P < 0.05; ^∗∗ P < 0.01.