Table 2.
Absolute values of the morphometric analysis for inflammatory, remodeling, and oxidative stress markers, in the alveolar walls. The neutrophils, macrophages, TNF-α, MMP-9, MMP-12, TIMP-1, iNOS, and eNOS are expressed in positive cells/104 µm2. The collagen fiber, elastic fiber, and 8-iso-PGF2α are expressed in percentage (%). ∗ P < 0.05, compared with the SAL and SAL-rBbKI groups; ∗∗ P < 0.05, compared with the ELA-rBbKI group.
| SAL | ELA | SAL-rBbKI | ELA-rBbKI | |
|---|---|---|---|---|
| Inflammatory markers | ||||
| Neutrophils (cells/104 μm2) | 0.33 ± 0.07 | 1.35 ± 0.14∗ | 0.55 ± 0.03 | 0.83 ± 0.78∗∗ |
| Macrophages (cells/104 μm2) | 0.36 ± 0.03 | 1.19 ± 0.05∗ | 0.68 ± 0.05 | 0.81 ± 0.41∗∗ |
| TNF-α (cells/104 μm2) | 2.86 ± 0.54 | 12.50 ± 1.28∗ | 4.85 ± 0.77 | 9.69 ± 0.91∗/∗∗ |
|
| ||||
| Remodeling markers | ||||
| Collagen fibers (%) | 9.64 ± 0.12 | 11.62 ± 0.83∗ | 7.75 ± 0.91 | 10.30 ± 2.85∗∗ |
| Elastic fibers (%) | 0.29 ± 0.05 | 0.47 ± 0.08∗ | 0.32 ± 0.10 | 0.30 ± 0.09∗∗ |
| MMP-9 (cells/104 μm2) | 6.39 ± 0.79 | 17.92 ± 0.86∗ | 7.90 ± 0.92 | 10,82 ± 1.96∗∗ |
| MMP-12 (cells/104 μm2) | 9.75 ± 0.92 | 21.46 ± 3.65∗ | 7.88 ± 1.32 | 13.21 ± 1.51∗∗ |
| TIMP-1 (cells/104 μm2) | 4.76 ± 0.53 | 13.58 ± 1.14∗ | 5.95 ± 0.60 | 6.80 ± 1.08∗∗ |
|
| ||||
| Oxidative stress markers | ||||
| iNOS (cells/104 μm2) | 4.52 ± 0.47 | 19.60 ± 2.75∗ | 6.23 ± 1.24 | 9.82 ± 1.13∗/∗∗ |
| eNOS (cells/104 μm2) | 4.13 ± 0.58 | 12.33 ± 1.87∗ | 5.85 ± 0.78 | 7,00 ± 1.05∗/∗∗ |
| 8-iso-PGF2α (%) | 1.51 ± 0.64 | 17.94 ± 1.30∗ | 1.48 ± 0.46 | 7.03 ± 1.25∗/∗∗ |