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Infusion of educated macrophages (EM) alters the systemic inflammatory response to LPS. In each group, blood and BAL samples were collected at 6, 24, and 48 h after LPS or PBS treatment. Cytokine concentrations were determined in a Luminex system. (a) Cytokine levels in serum (IFN-γ, IL-6, and IL-10). (b) Cytokine levels in BAL (IL-4, IL-6, IL-10, and IL-13). M = macrophages. All data are expressed as mean ± SEM; n = 4 per group. ∗ p < 0.05; ∗∗ p < 0.01; and ∗∗∗ p < 0.001.
