Table 2. Shared outlier SNPs inferred in two BayeScan analyses comparing East Asian (EA) dog breeds with FBDs or modern European (ME) breeds.
SNP ID | Chr | SNP Position CanFam2 | SNP Position CanFam3.1 | Substitution Type | Location Relative to Closest Gene | Gene Symbol | BayeScan EA vs. FBD | BayeScan EA vs. ME | Gene Function | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
q-Value | α | FST | q-Value | α | FST | ||||||||
BICF2G630560144; rs24457899 | 7 | 58,926,419 | 55,945,622 | A/G | Intron | NOL4 | 0.040 | 1.456 | 0.222 | 0.076 | 1.359 | 0.279 | Encodes nucleolar protein 4 expressed in fetal brain, adult brain, and testis |
BICF2P1348247; rs8579426 | 18 | 17,773,402 | 14,783,296 | A/C | Intron | ATXN7L1 | 0.124 | 1.274 | 0.204 | 0.059 | 1.602 | 0.317 | Associated with spinocerebellar ataxia type 7 in humans |
BICF2G630509420; rs23187455 | 24 | 14,905,265 | 11,907,423 | C/T | Intron | MKKS (BBS6) | 0.016 | 1.841 | 0.265 | 0.145 | 1.272 | 0.272 | Associated with McKusick–Kaufman syndrome and Bardet–Biedl syndrome type 6 in humans; secondary symptoms include genital abnormalities and dental crowding |
BICF2G630662694 | 13 | 35,179,641 | 32,140,606 | A/G | 257,806 3′-downstream | GAPDHS Homolog | 0.022 | 1.801 | 0.260 | 0.093 | 1.451 | 0.296 | Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; specifically expressed in spermatogenetic cells |
SNP, single nucleotide polymorphism; Chr, chromosome, EA, East Asian; FBD, free-breeding dogs; ME, modern European.