Skip to main content
. 2016 May 27;6(8):2343–2354. doi: 10.1534/g3.116.030767

Table 1. Genome-wide significant loci.

Chromosome Top SNP Position Top SNP logP FDR Size 95% CI (bp) Start Position 95% CI End Position 95% CI Number of Genes in 95% CI Gene Names MAF β Variance Explained (%)
2 29990674 5.21 0.017 661130 29606566 30267695 20 Rapgef1, Gm13547, Trub2, Coq4, Slc27a4, Urm1, Cercam, Odf2, Gle1, Sptan1, Wdr34, Set, Pkn3, Zdhhc12, Zer1, Tbc1d13, Endog, D2Wsu81e, Ccbl1, Lrrc8a 0.49 0.33 1.29
5 148761610 4.66 0.045 747871 148093705 148841575 3 Mtus2, Slc7a1, Ubl3 0.46 0.27 1.13
8 33158129 13.05 0 1312071 32889539 34201609 13 Wrn, Purg, Tex15, Ppp2cb, Ubxn8, Gsr, Gtf2e2, Smim18, Rbpms, Dctn6, Mboat4, Leprotl1, Saraf 0.38 0.59 4.46
9 109076890 5.43 0.015 624542 108855860 109480401 20 Slc26a6, Tmem89, Uqcrc1, Col7a1, Ucn2, Pfkfb4, Shisa5, Trex1, Atrip, Tma7, Ccdc51, Plxnb1, Fbxw21, Fbxw13, Fbxw20, Fbxw14, Fbxw14, Fbxw22, Fbxw16, Fbxw19 0.20 0.46 1.77
10 121477912 8.55 0 476002 121229924 121705925 6 Tbc1d30, Gns, Rassf3, Tbk1, Xpot, D930020B18Rik 0.50 0.46 2.98
11 69570999 8.21 0 1055268 68747919 69803186 49 Myh10, Ndel1, Rnf222, Rpl26, Odf4, Arhgef15, Slc25a35, Rangrf, Pfas, Ctc1, Aurkb, 2310047M10Rik, Tmem107, Vamp2, Per1, Hes7, Aloxe3, Alox12b, Alox8, Gucy2e, Cntrob, Trappc1, Kcnab3, Chd3, Cyb5d1, Naa38, Tmem88, Kdm6b, Dnah2, Efnb3, Wrap53, Trp53, Atp1b2, Shbg, Sat2, Fxr2, Sox15, Mpdu1, Cd68, Eif4a1, Senp3, Tnfsfm1 3, Tnfsf13, Tnfsf12, Polr2a, Slc35g3, Zbtb4, Chrnb1, Fgf11 0.45 0.45 2.55
17 34159865 9.25 0 1456751 34145616 35602366 86 H2-DMb2, H2-DMb1, Psmb9, Tap1, Psmb8, Tap2, H2-Ob, H2-Ab1, H2-Aa, H2-Eb1, H2-Eb2, Btnl2, Btnl1, BC051142, Btnl4, Btnl6, Notch4, Gpsm3, Pbx2, Ager, Rnf5, Agpat1, Egfl8, Ppt2, Prrt1, Fkbpl, Atf6b, Tnxb, C4b, Cyp21a1, Stk19, Dxo, Skiv2l, Nelfe, Cfb, C2, Zbtb12, Ehmt2, Slc44a4, Neu1, Hspa1b, Hspa1a, Hspa1l, Lsm2, Vars, Vwa7, Sapcd1, Msh5, Clic1, Ddah2, G6b, Ly6g6c, Ly6g6d, Ly6g6e, Ly6g6f, Abhd16a, Ly6g5c, Ly6g5b, Csnk2b, Gpank1, D17H6S53E, Apom, Bag6, Prrc2a, Aif1, Lst1, Ltb, Tnf, Lta, Nfkbil1, Atp6v1g2, Ddx39b, H2-D1, H2-Q1, H2-Q2, H2-Q4, H2-Q6, H2-Q7, H2-Q10, Pou5f1, Tcf19, Cchcr1, Psors1c2, Cdsn, 2300002M23Rik, Sfta2 0.38 0.74 3.16

Shown are the seven genome-wide significant loci for micronucleus levels and the genes within the 95% confidence intervals. The start and end positions of each QTL are provided, and the minor allele frequency (MAF), β, and effect size (variance explained) of the top scoring SNP. These QTL positions were defined using the entire collection of SNPs for higher mapping resolution. Note that the -logP value given in the table is the maximum among all imputed SNPs under the QTL, which is generally higher than that shown on Fig 1D.