Table 1. Genome-wide significant loci.
| Chromosome | Top SNP Position | Top SNP logP | FDR | Size 95% CI (bp) | Start Position 95% CI | End Position 95% CI | Number of Genes in 95% CI | Gene Names | MAF | β | Variance Explained (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | 29990674 | 5.21 | 0.017 | 661130 | 29606566 | 30267695 | 20 | Rapgef1, Gm13547, Trub2, Coq4, Slc27a4, Urm1, Cercam, Odf2, Gle1, Sptan1, Wdr34, Set, Pkn3, Zdhhc12, Zer1, Tbc1d13, Endog, D2Wsu81e, Ccbl1, Lrrc8a | 0.49 | 0.33 | 1.29 |
| 5 | 148761610 | 4.66 | 0.045 | 747871 | 148093705 | 148841575 | 3 | Mtus2, Slc7a1, Ubl3 | 0.46 | 0.27 | 1.13 |
| 8 | 33158129 | 13.05 | 0 | 1312071 | 32889539 | 34201609 | 13 | Wrn, Purg, Tex15, Ppp2cb, Ubxn8, Gsr, Gtf2e2, Smim18, Rbpms, Dctn6, Mboat4, Leprotl1, Saraf | 0.38 | 0.59 | 4.46 |
| 9 | 109076890 | 5.43 | 0.015 | 624542 | 108855860 | 109480401 | 20 | Slc26a6, Tmem89, Uqcrc1, Col7a1, Ucn2, Pfkfb4, Shisa5, Trex1, Atrip, Tma7, Ccdc51, Plxnb1, Fbxw21, Fbxw13, Fbxw20, Fbxw14, Fbxw14, Fbxw22, Fbxw16, Fbxw19 | 0.20 | 0.46 | 1.77 |
| 10 | 121477912 | 8.55 | 0 | 476002 | 121229924 | 121705925 | 6 | Tbc1d30, Gns, Rassf3, Tbk1, Xpot, D930020B18Rik | 0.50 | 0.46 | 2.98 |
| 11 | 69570999 | 8.21 | 0 | 1055268 | 68747919 | 69803186 | 49 | Myh10, Ndel1, Rnf222, Rpl26, Odf4, Arhgef15, Slc25a35, Rangrf, Pfas, Ctc1, Aurkb, 2310047M10Rik, Tmem107, Vamp2, Per1, Hes7, Aloxe3, Alox12b, Alox8, Gucy2e, Cntrob, Trappc1, Kcnab3, Chd3, Cyb5d1, Naa38, Tmem88, Kdm6b, Dnah2, Efnb3, Wrap53, Trp53, Atp1b2, Shbg, Sat2, Fxr2, Sox15, Mpdu1, Cd68, Eif4a1, Senp3, Tnfsfm1 3, Tnfsf13, Tnfsf12, Polr2a, Slc35g3, Zbtb4, Chrnb1, Fgf11 | 0.45 | 0.45 | 2.55 |
| 17 | 34159865 | 9.25 | 0 | 1456751 | 34145616 | 35602366 | 86 | H2-DMb2, H2-DMb1, Psmb9, Tap1, Psmb8, Tap2, H2-Ob, H2-Ab1, H2-Aa, H2-Eb1, H2-Eb2, Btnl2, Btnl1, BC051142, Btnl4, Btnl6, Notch4, Gpsm3, Pbx2, Ager, Rnf5, Agpat1, Egfl8, Ppt2, Prrt1, Fkbpl, Atf6b, Tnxb, C4b, Cyp21a1, Stk19, Dxo, Skiv2l, Nelfe, Cfb, C2, Zbtb12, Ehmt2, Slc44a4, Neu1, Hspa1b, Hspa1a, Hspa1l, Lsm2, Vars, Vwa7, Sapcd1, Msh5, Clic1, Ddah2, G6b, Ly6g6c, Ly6g6d, Ly6g6e, Ly6g6f, Abhd16a, Ly6g5c, Ly6g5b, Csnk2b, Gpank1, D17H6S53E, Apom, Bag6, Prrc2a, Aif1, Lst1, Ltb, Tnf, Lta, Nfkbil1, Atp6v1g2, Ddx39b, H2-D1, H2-Q1, H2-Q2, H2-Q4, H2-Q6, H2-Q7, H2-Q10, Pou5f1, Tcf19, Cchcr1, Psors1c2, Cdsn, 2300002M23Rik, Sfta2 | 0.38 | 0.74 | 3.16 |
Shown are the seven genome-wide significant loci for micronucleus levels and the genes within the 95% confidence intervals. The start and end positions of each QTL are provided, and the minor allele frequency (MAF), β, and effect size (variance explained) of the top scoring SNP. These QTL positions were defined using the entire collection of SNPs for higher mapping resolution. Note that the -logP value given in the table is the maximum among all imputed SNPs under the QTL, which is generally higher than that shown on Fig 1D.