Figure 4.

Mucus accumulation in the sinuses. (A–D) Coronal sections of the maxillary sinuses (ms) from mutant and littermate wild-type mice are stained using hematoxylin and eosin. Higher magnification images of the boxed region (a–f for wild-type and a’–f’ for mutants) are shown in lower panels. e and e’ are from more posterior paranasal cavity sections. Severe mucus accumulation and infiltration of neutrophils (c’) were obvious in a Dnaaf1^m4Bei mutant at P7. Lrrc48^m6Bei mutants show milder phenotype that is undetectable until later (16 week-old). Scale bars: A–D, 1 mm; a, a’, b, b’, d’, e, and e’, 100 μm; c, c’, f, and f’, 25 μm.