Table 2. Regulators of CDKN1A/p21 and BBC3/puma.
| Downregulated by siRNA | Upregulated by siRNA | ||
|---|---|---|---|
| (Positive Regulator) | (Negative Regulator) | ||
| DMSO | Etoposide | DMSO | Etoposide |
| TP53 | PLK1 | CTCF& | JHDM1D |
| SETD3 | TP53 | MLL2 | |
| NCAPG | PRMT6 | YEATS4 | |
| MBD3L2* | TRERF1 | ||
| TOP1 | EP300& | ||
| SETDB1 | SRCAP& | ||
| PHC1 | USP27X | ||
| HIRIP3& | |||
| KIAA1267& | |||
Genes are listed in order of strongest to weakest phenotypic effect. Full phenotypic values can be found in Table S1. * and & denote putative false positives and secondary screen hits, respectively. Information about identification of putative false positives and secondary screen hits can be found in Materials and Methods. siRNA, small interfering RNA; DMSO, dimethyl sulfoxide.