. Author manuscript; available in PMC: 2016 Aug 10.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2011 Jun 2;82(5):1851–1857. doi: 10.1016/j.ijrobp.2011.03.029

Table 4.

Literature on oropharyngeal cancer primary gross tumor volume and disease control

					pGTV
					p value	p value
Author	Year	N	RT technique	Patients on CCRT	LC/LRC	DMFS
Nathu et al.	2000	114	3D-CRT	11%^*	0.1	–
Mendenhall et al.	2003	190	3D-CRT	4%	0.0892–0.9493	–
Keberle et al.	2003	80	3D-CRT	NR	0.19	–
Been et al.	2008	79	3D-CRT/IMRT	49%	0.6244	–
Hermans et al.	2001	112	3D-CRT	NR	0.047
Chao et al.	2004	31^†	IMRT	55%	0.03	0.03
Struder et al.	2007	85^†	IMRT	75%^‡	<0.001	–
Present study	2010	340	IMRT	95%	0.004	0.0008

Abbreviations: 3D-CRT = three-dimensional conventional radiotherapy; CCRT = concurrent chemoradiotherapy; DMFS = distant metastasis–free survival; IMRT = intensity-modulated radiation therapy; LC = local control; LRC = locoregional control; NR = not reported; pGTV = primary gross tumor volume.

Patients underwent induction chemotherapy.

^†

Subset of patients included in volumetric analysis.

^‡

CCRT rate is based on the total head-and-neck cancer cohort of 172 patients. Numbers in boldface type indicate p-values are statistically significant.