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. 2016 Aug 10;6:30610. doi: 10.1038/srep30610

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Copyright © 2016, The Author(s)

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(A,B) Examples of mitochondrial nanotunnels composed of both OMM and IMM, but devoid of cristae in a case of m.3243A>G (patient 7). (C) Variation in nanotunnel diameter, with each datapoint representing the average of the smallest and largest diameters measured for individual nanotunnels across all subjects (n = 26). (D) Three-dimensional reconstruction of three mitochondria connected via nanotunnels from a case of m.3242A>G (patient 7). (E,F) Examples of highly branched mitochondria (hyperfusion) from cases of m.3243A>G (patient 7) (G) Donut-shaped mitochondrion denoting self-fusion from a case of single mtDNA deletion (patient 2). (H) Three-dimensional reconstruction of a donut-shaped mitochondrion from a case of m.8344A>G (patient 6).