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. 2016 Aug 10;6:31267. doi: 10.1038/srep31267

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Copyright © 2016, The Author(s)

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(A) The number of differentially expressed miRNAs after 1/3 and 2/3 PH compared to normal liver controls. (B) The number of preferentially expressed miRNAs after 2/3 PH compared to 1/3 PH. (C) Densities representing the distribution of all miRNAs at 6 (blue), 12 (yellow), 24 (green), and 36 hours (red) after PH; the dotted line indicates the threshold of a 1.2 fold-change. The distribution of miRNA changes at 6, 12, 24, and 36 hours showed a shift in 1/3 PH vs normal control and 2/3 PH vs 1/3 PH. (D) Principal component analysis of all investigated samples showed that 1/3 PH induced a fluctuation with a trend to close to that of normal liver over time, while 2/3 PH diverged away from normal liver. 0, normal liver; 1, 3, 5, and 7 represent 6, 12, 24, 36 and hours after 1/3PH, respectively; 2, 4, 6, and 8 represent 6, 12, 24, and 36 hours after 2/3PH, respectively.