Figure 3.

Effects of nicotine dose reduction on body weight gain. Body weight gain in rats where dose was reduced from 60 µg/kg/infusion to: Maintained at 60 (n = 11), 15 (n = 10), 7.5 (n = 11), 3.75 (n = 11), 1.875 (n = 10), or 0 (n = 13) µg/kg/infusion nicotine. Reduction of nicotine dose resulted in significant increases in body weight gain compared to constant self-adminstration of 60 µg/kg/infusion nicotine. * indicates 60 µg/kg/infusion different from 3.75 and 1.875 µg/kg/infusion. All Ps < .01.