Table 1.
Characteristics of Individuals from Nicotine Metabolism Laboratory Studies (N = 312)
| Study | 588 | PKTWINa | SMOFAMa | P | ||
|---|---|---|---|---|---|---|
| Ancestry | African | Asian | European | European | European | |
| N | 49 | 51 | 67 | 95 | 50 | |
| Age, M (SD) | 38.3 (11.3) | 28.3 (7.41) | 34.3 (12.2) | 36.9 (11.8) | 28.1 (1.38) | <.0001 |
| Sex (% F) | 38.7 | 49.0 | 44.8 | 74.7 | 58.0 | <.0001 |
| BMI, M (SD) | 26.5 (4.20) | 23.8 (2.87) | 24.9 (3.71) | 25.1 (4.13) | 28.6 (7.28) | <.0001 |
| Smoking (%) | 53.1 | 29.4 | 56.7 | 18.9 | 46.0 | <.0001 |
| NMR | −1.79 (0.50) | −1.84 (0.56) | −1.42 (0.47) | −1.47 (0.57) | −1.46 (0.45) | 0.0076 |
588 and SMOFAM = oral administration of labeled nicotine and cotinine and collection and analysis of saliva (SMOFAM, only saliva) and blood (plasma); PKTWIN = venous administration of labeled nicotine and cotinine and analysis of blood (plasma); Natural log transformed nicotine metabolite ratio (NMR) values are reported.
aUnrelated individuals only.