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. 2016 Aug 10;6:31071. doi: 10.1038/srep31071

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Copyright © 2016, The Author(s)

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(A) IHC in consecutive sections of GIST tumor tissues showed that CCBE1 co-localized in the blood vessels wall with vascular marker CD31, nor with lymphatic marker LYVE-1 (Original magnification: 200×; Scale bars, 200 μm). (B) Tube formation assay showed that rCCBE1 protein could promote angiogenesis in concentration-dependent manner in vitro, tube number per field was measured to reflect the pro-angiogenic effect of rCCBE1 (Original magnification: 100×; Scale bars, 200 μm; ***p < 0.001, **p < 0.01, *p < 0.05).