Table 2.

Cox proportional hazard regression analyses in relation to the composite outcome of death or cardiac hospitalization

Variable	Planned Model* Hazard Ratio (95% CI)	P Value	Extended Model† Hazard Ratio (95% CI)	P Value
Etiology	1.773 (1.151–2.730)	0.009	2.167 (1.343–3.496)	0.002
LVEF	0.973 (0.953–0.993)	0.009	0.972 (0.953–0.992)	0.006
NT-ProBNP	1.234 (1.114–1.368)	<0.0001	1.227 (1.107–1.360)	<0.0001
Age	0.914 (0.756–1.103)	0.35	0.920 (0.764–1.107)	0.38
Baseline HR	1.020 (1.000–1.039)	0.047	1.020 (1.001–1.040)	0.040
Baseline Arterial Diameter	1.232 (0.903–1.680)	0.19	1.284 (0.931–1.171)	0.13
FMD	1.046 (0.980–1.117)	0.17	1.062 (0.993–1.135)	0.08
Hyperemic Flow	0.923 (0.867–0.983)	0.013	0.912 (0.854–0.973)	0.0055
Hyperlipidemia	-	-	1.528 (0.963–2.426)	0.07

Note: CI = confidence interval; LVEF = left ventricular ejection fraction; NT Pro-BNP = N-terminal pro-natriuretic peptide; HR = heart rate; FMD = flow-mediated dilation. NT-proBNP was expressed as NT-proBNP/1000, age was expressed as age/10 and hyperemic flow was expressed as hyperemic flow/1000.

^*Adjusted for etiology, LVEF, NT-ProBNP, age, baseline HR, baseline arterial diameter, hyperemic flow and FMD.

^†Adjusted for the variables in the a priori planned model, as well as hyperlipidemia