Table 5. Chromosomal regions (0 to 3 Mbp) harboring four or more significantly associated SNPs with the same or different fatty acid traits and termed association hot spots in this study.
| Chromosomal location (size in Mbp) | Marker | Position | RS# or SS# | Minor/Major Allele | Classification | Gene(s) | P-Value | P-Value BH FDR | Proportion Variance Explained | MAF | Fatty acid |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chr 10 81299090 to 83656836 (2.36 Mbp) | S10_81299090 | 81299090 | rs469048969 | C/G | UTR3 | TMEM229B | 0.000679 | 0.08942 | 0.014 | 0.021 | C13:0 |
| S10_81311811 | 81311811 | rs211170312 | A/G | Intronic | TMEM229B | 3.65E-06 | 0.005572 | 0.025 | 0.037 | C6:0 | |
| S10_81311811 | 81311811 | rs211170312 | A/G | Intronic | TMEM229B | 6E-05 | 0.064553 | 0.019 | 0.037 | C8:0 | |
| S10_81524148 | 81524148 | rs379783190 | A/C | Intergenic | — | 4.91E-05 | 0.035386 | 0.019 | 0.017 | C6:0 | |
| S10_82071253 | 82071253 | rs381605268 | A/G | Intronic | RAD51B | 2.99E-07 | 0.003042 | 0.031 | 0.017 | C20:4n6 | |
| S10_83656836 | 83656836 | ss1850096308 | G/T | Intronic | SMOC1 | 0.00013 | 0.094105 | 0.018 | 0.017 | C24:0 | |
| Chr 11 102189029 to 103096195 (0.91 Mbp) | S11_102189029 | 102189029 | rs472815046 | G/T | Intergenic | — | 2.78E-06 | 0.005448 | 0.027 | 0.017 | C24:0 |
| S11_102513057 | 102513057 | ss1850113339 | G/T | Splicing | ODF2 | 7.29E-05 | 0.045339 | 0.019 | 0.040 | C24:0 | |
| S11_102912346 | 102912346 | ss1850113453 | C/A | Intronic | LRRC8A | 4.84E-05 | 0.022963 | 0.019 | 0.032 | C13:0 | |
| S11_103096195 | 103096195 | ss1850113566 | C/A | Intronic | PPP2R4 | 2.14E-05 | 0.040245 | 0.021 | 0.018 | C4:0 | |
| S11_103096195 | 103096195 | ss1850113566 | C/A | Intronic | PPP2R4 | 1.96E-06 | 0.003555 | 0.027 | 0.018 | C6:0 | |
| S11_103096195 | 103096195 | ss1850113566 | C/A | Intronic | PPP2R4 | 0.000102 | 0.083004 | 0.019 | 0.018 | C8:0 | |
| Chr 17 75239193 to 75857466 (0.618 Mbp) | S17_75239193 | 75239193 | rs440208182 | G/T | Downstream | MIR130B, MIR301B | 3.72E-05 | 0.019058 | 0.020 | 0.016 | C13:0 |
| S17_75451270 | 75451270 | rs468894370 | G/T | Intronic | AIFM3 | 0.000142 | 0.066741 | 0.018 | 0.023 | C24:0 | |
| S17_75458648 | 75458648 | rs381895058 | G/A | Intronic | LZTR1 | 0.000384 | 0.064358 | 0.015 | 0.019 | C13:0 | |
| S17_75636645 | 75636645 | ss1850185522 | G/A | Intronic | KLHL22 | 0.000432 | 0.089446 | 0.015 | 0.060 | C13:0 | |
| S17_75825603 | 75825603 | rs207929394 | T/C | Intergenic | — | 1.59E-05 | 0.011326 | 0.023 | 0.047 | C13:0 | |
| S17_75857466 | 75857466 | ss1850185673 | G/T | Intronic | CDC45 | 2.83E-05 | 0.0159 | 0.021 | 0.039 | C13:0 | |
| Chr 22 51831131 to 53880151 (2.05 Mbp) | S22_51831131 | 51831131 | rs473131453 | G/T | Intronic | SLC25A20 | 2.27E-06 | 0.003938 | 0.026 | 0.018 | C6:0 |
| S22_51831131 | 51831131 | rs473131453 | G/T | Intronic | SLC25A20 | 1.82E-05 | 0.02778 | 0.022 | 0.018 | C8:0 | |
| S22_51965717 | 51965717 | ss1850241844 | C/A | UTR3 | NCKIPSD | 6.41E-06 | 0.00924 | 0.025 | 0.018 | C24:0 | |
| S22_52346974 | 52346974 | rs110791336 | T/G | Intergenic | — | 0.000161 | 0.050409 | 0.017 | 0.066 | C13:0 | |
| S22_52379056 | 52379056 | ss1850241914 | G/T | Coding | CCDC51 | 0.000691 | 0.090064 | 0.014 | 0.037 | C13:0 | |
| S22_52380263 | 52380263 | ss1850241922 | C/T | Coding | CCDC51 | 0.000451 | 0.090988 | 0.015 | 0.022 | C13:0 | |
| S22_53719765 | 53719765 | ss1850242135 | G/T | Intronic | MYL3 | 1.48E-05 | 0.066302 | 0.027 | 0.015 | C23:0 | |
| S22_53880151 | 53880151 | rs477695948 | C/A | Coding | ALS2CL | 0.000107 | 0.054515 | 0.019 | 0.025 | C24:0 | |
| Chr 22 55449849 to 56791780 (1.35 Mbp) | S22_55449849 | 55449849 | rs110927574 | G/A | Intronic | GHRL | 1.77E-07 | 0.000615 | 0.031996 | 0.0184 | C6:0A |
| S22_55449849 | 55449849 | rs110927574 | G/A | Intronic | GHRL | 2.88E-07 | 0.001481 | 0.030908 | 0.0184 | C8:0A | |
| S22_55451203 | 55451203 | rs109410906 | A/G | Intronic | GHRL | 0.000111 | 0.075601 | 0.017662 | 0.0314 | C6:0D | |
| S22_55494482 | 55494482 | rs42013770 | G/A | Intronic | SEC13 | 1.44E-06 | 0.002899 | 0.027315 | 0.0329 | C6:0A | |
| S22_55494482 | 55494482 | rs42013770 | G/A | Intronic | SEC13 | 1.05E-05 | 0.020434 | 0.022899 | 0.0329 | C8:0A | |
| S22_55554117 | 55554117 | rs469316661 | C/A | Intronic | ATP2B2 | 1.37E-06 | 0.005244 | 0.027425 | 0.0185 | C4:0A | |
| S22_56478689 | 56478689 | ss1850242913 | G/T | Intronic | ATG7 | 6.25E-05 | 0.05658 | 0.018929 | 0.019 | C6:0D | |
| S22_56478689 | 56478689 | ss1850242913 | G/T | Intronic | ATG7 | 2.83E-05 | 0.035383 | 0.02069 | 0.019 | C8:0A | |
| S22_56791780 | 56791780 | ss1850243003 | A/T | Intronic | ATG7 | 0.000172 | 0.074627 | 0.017434 | 0.0694 | C24:0A | |
| Chr 28 41433808 to 43479268 (2.04 Mbp) | S28_41433808 | 41433808 | rs475314514 | T/C | Intronic | GLUD1 | 5.56E-07 | 0.002831 | 0.029443 | 0.0302 | C4:0A |
| S28_41433849 | 41433849 | rs466502048 | C/T | Intronic | GLUD1 | 0.000165 | 0.051037 | 0.016783 | 0.0155 | C13:0A | |
| S28_41435026 | 41435026 | ss1850132183 | A/G | Intronic | GLUD1 | 2.95E-05 | 0.064795 | 0.020599 | 0.0173 | C4:0D | |
| S28_41634323 | 41634323 | ss1850295121 | G/T | Intergenic | — | 4.17E-05 | 0.03122 | 0.020707 | 0.0261 | C24:0A | |
| S28_41748027 | 41748027 | ss1850295146 | C/A | Intergenic | — | 5.7E-07 | 0.001675 | 0.030684 | 0.0165 | C24:0A | |
| S28_41994199 | 41994199 | rs42148747 | T/C | Intergenic | — | 0.000191 | 0.054817 | 0.016462 | 0.0533 | C13:0A | |
| S28_42004219 | 42004219 | rs42148747 | C/A | Coding | RBP3 | 3.65E-05 | 0.01884 | 0.020122 | 0.0222 | C13:0A | |
| S28_42639526 | 42639526 | ss1850295342 | C/A | Intergenic | — | 7.74E-05 | 0.084457 | 0.018456 | 0.0168 | C4:0A | |
| S28_43479268 | 43479268 | rs470755489 | G/C | Coding | ERCC6 | 2.49E-05 | 0.050122 | 0.022174 | 0.1121 | C20:5n3A | |
| Chr 29 42815829 to 45731092 (2.9 Mbp) | S29_42815829 | 42815829 | rs447920602 | G/T | Intronic | SLC22A8 | 0.000104 | 0.074691 | 0.017793 | 0.0155 | C6:0D |
| S29_43911453 | 43911453 | rs132922154 | C/A | Intronic | MACROD1 | 0.000459 | 0.091729 | 0.014533 | 0.0167 | C13:0A | |
| S29_43949399 | 43949399 | ss1850302054 | A/G | Intronic | MACROD1 | 2.83E-05 | 0.024879 | 0.020684 | 0.0233 | C6:0A | |
| S29_43949399 | 43949399 | ss1850302054 | A/G | Intronic | MACROD1 | 9.68E-05 | 0.082102 | 0.017963 | 0.0233 | C8:0A | |
| S29_43950350 | 43950350 | rs451632156 | T/C | Intronic | MACROD1 | 4.4E-08 | 0.000258 | 0.035107 | 0.0161 | C6:0A | |
| S29_43950350 | 43950350 | rs451632156 | T/C | Intronic | MACROD1 | 1.86E-07 | 0.00129 | 0.031889 | 0.0161 | C8:0A | |
| S29_44467997 | 44467997 | ss1850302313 | C/A | Intronic | NRXN2 | 0.00018 | 0.052768 | 0.016598 | 0.0161 | C13:0A | |
| S29_44684726 | 44684726 | rs435582482 | G/T | Intronic | EHD1 | 0.00073 | 0.092593 | 0.013517 | 0.0235 | C13:0D | |
| S29_45566049 | 45566049 | ss1850302687 | C/G | Coding | DKFZP761E198 | 2.35E-06 | 0.002742 | 0.026226 | 0.0179 | C13:0A | |
| S29_45731092 | 45731092 | rs436614558 | T/G | Coding | C29H11orf68 | 2.38E-05 | 0.014305 | 0.021074 | 0.0172 | C13:0A |