Table 1. Craniofacial phenotypes after transient and continuous embryonic exposure.
| Exposure | STAGE | Group | BD1, % | JB, % | DV, % | HB, % | BE % of control |
|---|---|---|---|---|---|---|---|
| Transient exposure | 24 h, 2 dph (13 dpe2) | Control | 0 | 0 | 0 | 0 | — |
| Low dose | 0 | 0 | 0 | 0 | — | ||
| Pulse dose | 0 | 0 | 0 | 0 | — | ||
| High dose | 7 | 0 | 3 | 0 | — | ||
| 48 h, 2 dph (12 dpe) | Control | 0 | 0 | 0 | 0 | — | |
| Low dose | 0 | 0 | 0 | 0 | — | ||
| Pulse dose | 0 | 0 | 0 | 0 | — | ||
| High dose | 17 | 0 | 10 | 3 | — | ||
| Continuous embryonic exposure | E0 dph (3 dpe) | Control | — | — | — | — | 100 ± 21a |
| Low dose | — | — | — | — | 74 ± 23b | ||
| Pulse dose | — | — | — | — | 86 ± 13c | ||
| High dose | — | — | — | — | 86 ± 16c | ||
| 3 dph (6 dpe) | Control | 1 ± 3a | 0a | 0a | 0a | — | |
| Low dose | 17 ± 7b | 15 ± 18b | 2 ± 3b | 0a | — | ||
| Pulse dose | 28 ± 8c | 2 ± 3a,c | 27 ± 19c | 0a | — | ||
| High dose | 15 ± 9b | 4 ± 5c | 23 ± 10c | 54 ± 19b | — |
1BD, bulldog; JB, jaw breaker; DV, Darth Vader; HB, hunchback; BE, distance between eyes.
a–dLetters indicate significant differences between groups (p = <0.05) (groups with same letters are not significantly different from each other).
2Dpe = days post exposure stop.