Table 2.
List of genes upregulated in the liver of the TTX-administered pufferfish Takifugu rubripes group compared to those in the buffer-administered control group (FC 1 >3.0).
| Ensemble ID | Gene name | Predicted description | Functional classification | FC |
|---|---|---|---|---|
| ENSTRUT00000045544 | Cela2a | Chymotrypsin-like elastase family member 2A | Enzyme, cofactor | 37.6 |
| ENSTRUT00000041722 | Tmem168 | Transmembrane protein 168 | Transport vesicle | 20.0 |
| ENSTRUT00000006023 | Arhgap29 | Rho GTPase-activating protein 29 | Enzyme, cofactor | 12.1 |
| ENSTRUT00000034782 | Kcnma1 | T. rubripes calcium channel alpha-1 subunit homolog (AF026198.1) | Ion channel activity | 10.4 |
| ENSTRUT00000004724 | Chrna9 | T. rubripes nicotinic acetylcholine receptor alpha 9d subunit (AY299471.1) | Ion channel activity | 8.1 |
| ENSTRUT00000038610 | Csmd1 | CUB and sushi domain-containing protein 1 | Protein binding | 7.0 |
| ENSTRUT00000036792 | Serinc4 | Serine incorporator 4 | Transporter activity | 6.8 |
| ENSTRUT00000026094 | C14orf135 | Pecanex-like protein C14orf135 | Unknown | 6.6 |
| ENSTRUT00000046072 | Lrp2 | Low density lipoprotein receptor-related protein 2 | Receptor activity | 5.4 |
| ENSTRUT00000046718 | Col27a1 | Collagen alpha-1(XXVII) chain A-like | Structural molecule | 5.2 |
| ENSTRUT00000000397 | Klhl32 | Kelch-like protein 32 | Protein binding | 4.5 |
| ENSTRUT00000000173 | Elk4 | ELK4, ETS-domain protein | Transcription factor | 4.3 |
| ENSTRUT00000025902 | Zbtb45 | Zinc finger and BTB domain-containing protein 45 | Transcription factor | 4.3 |
| ENSTRUT00000020252 | Spsb1 | SPRY domain-containing SOCS box protein 1 | Receptor activity | 4.3 |
| ENSTRUT00000032342 | Dysf | Dysferlin | Lipid binding | 4.1 |
| ENSTRUT00000003310 | Scn2b | Sodium channel beta-2 subunit | Ion channel activity | 4.0 |
| ENSTRUT00000011167 | Loxl2 | Lysyl oxidase homolog 2 | Enzyme, cofactor | 3.9 |
| ENSTRUT00000017057 | Dmbx1 | Diencephalon/mesencephalon homeobox protein 1 | Transcription factor | 3.9 |
| ENSTRUT00000023088 | Clk2 | Dual specificity protein kinase CLK2 | Enzyme, cofactor | 3.9 |
| ENSTRUT00000045827 | Myo3b | Myosin-IIIb | Enzyme, cofactor | 3.8 |
| ENSTRUT00000025143 | Megf11 | Multiple epidermal growth factor-like domains protein 11 | Metal ion binding | 3.7 |
| ENSTRUT00000003539 | Slc44a1 | Choline transporter-like protein 1 | Transporter activity | 3.7 |
| ENSTRUT00000017798 | Cc4 | Carbonic anhydrase 4 | Enzyme, cofactor | 3.5 |
| ENSTRUT00000006962 | OR4563-2 | T. rubripes odorant receptor (DQ306241.1) | Receptor activity | 3.5 |
| ENSTRUT00000024316 | Pitpnm2 | Membrane-associated phosphatidylinositol transfer protein 2 | Metal ion binding | 3.4 |
| ENSTRUT00000030952 | Ptafr | Platelet-activating factor receptor | Receptor activity | 3.4 |
| ENSTRUT00000038903 | Hepacam2 | HEPACAM family member 2 | Unknown | 3.4 |
| ENSTRUT00000043658 | Gpr22 | Probable G-protein coupled receptor 22 | Receptor activity | 3.3 |
| ENSTRUT00000031306 | Ptpn2 | Tyrosine-protein phosphatase non-receptor type 2 | Enzyme, cofactor | 3.3 |
| ENSTRUT00000019629 | Eps15l1 | Epidermal growth factor receptor substrate 15-like 1 | Receptor activity | 3.2 |
| ENSTRUT00000036590 | Zdhhc8 | Membrane-associated DHHC8 zinc finger protein (NM_001078596.1) | Enzyme, cofactor | 3.2 |
| ENSTRUT00000031045 | Rheb | GTP-binding protein Rheb | Enzyme, cofactor | 3.2 |
| ENSTRUT00000047583 | Agap2 | Arf GAP with GTPase domain, ankyrin repeat and PH domain 2 | Enzyme, cofactor | 3.0 |
| ENSTRUT00000017824 | Ppargc1a | Peroxisome proliferator activated receptor gamma coactivator 1 alpha (DQ157766.1) | Receptor activity | 3.0 |
| ENSTRUT00000027961 | Pfkp | 6-phosphofructokinase type C | Enzyme, cofactor | 3.0 |
| ENSTRUT00000029743 | E2f2 | Transcription factor E2F2 | Unknown | 3.0 |
1 FC is the average fold change of the TTX-administered (n = 5) compared to the buffer-administered control group (n = 5).