Table 3.

List of genes downregulated in the liver of the TTX-administered pufferfish Takifugu rubripes group compared to those in the buffer-administered control group (FC ¹ > 3.0).

Ensemble ID	Gene name	Predicted description		Functional classification		FC
ENSTRUT00000047556	Fusa2	Elongation factor G 2		Transcription factor		−3.0
ENSTRUT00000009260	Rspo3	R-spondin-3		Transduction		−7.8
ENSTRUT00000029878	Ncoa2	Nuclear receptor coactivator 2		Transcription factor		−7.3
ENSTRUT00000005082	Sasb	Fatty acyl-CoA hydrolase precursor, medium chain		Enzyme, cofactor		−6.2
ENSTRUT00000042623	Kcnj3	G protein-activated inward rectifier potassium channel 1		Ion channel activity		−5.9
ENSTRUT00000029012	Galnt1	Polypeptide N-acetylgalactosaminyltransferase 1		Enzyme, cofactor		−5.7
ENSTRUT00000034755	Stk11ip	Serine/threonine kinase 11-interacting protein		Protein binding		−5.5
ENSTRUT00000007314	Unc5d	Netrin receptor UNC5D		Receptor activity		−5.3
ENSTRUT00000024559	Dnmt3a	DNA (cytosine-5)-methyltransferase 3A		Transcription factor		−4.7
ENSTRUT00000028271	finTRIM	Fish virus induced TRIM protein		Metal ion binding		−4.7
ENSTRUT00000021561	Synpo2	Synaptopodin-2		Protein binding		−4.4
ENSTRUT00000035155	Klhl8	Kelch-like protein 8		Protein binding		−4.4
ENSTRUT00000013283	Lnx2	Ligand of Numb protein X2		Metal ion binding		−4.3
ENSTRUT00000005282	Sox5	T. rubripes transcription factor SOX5 (AY277973.1)		Transcription factor		−4.1
ENSTRUT00000004950	Egr3	Early growth response protein 3		Transcription factor		−4.0
ENSTRUT00000001876	Nme1	Nucleoside diphosphate kinase A		Transcription factor		−4.0
ENSTRUT00000037748	Cadm2	Cell adhesion molecule 2		Protein binding		−3.9
ENSTRUT00000029148	Cln3	Battenin		Enzyme, cofactor		−3.8
ENSTRUT00000018412	Hecd3	Probable E3 ubiquitin-protein ligase HECTD3		Protein binding		−3.7
ENSTRUT00000010231	Wipi2	WD repeat domain phosphoinositide-interacting protein 2		Enzyme, cofactor		−3.7
ENSTRUT00000038056	Angpt2	Angiopoietin-2		Receptor activity		−3.7
ENSTRUT00000011781	-	Putative F-type lectin		Sugar binding		−3.6
ENSTRUT00000025271	Tyro3	Tyrosine-protein kinase receptor TYRO3		Transduction		−3.6
ENSTRUT00000036834	Pcolce	T. rubripes procollagen C-endopeptidase enhancer 1 (AF016494.1)		Protein binding		−3.4
ENSTRUT00000009581	Rims1	Regulating synaptic membrane exocytosis protein 1		Protein binding		−3.4
ENSTRUT00000013940	Pdlim5	PDZ and LIM domain protein 5		Protein binding		−3.4
ENSTRUT00000041778	Foxa3	T. rubripes folkhead transcription factor FoxA3 (AB604763.1)		Transcription factor		−3.3
ENSTRUT00000026385	Fam70a	Protein FAM70A		Unknown		−3.3
ENSTRUT00000003229	Arhgef26	Rho guanine nucleotide exchange factor 26		Transcription factor		−3.2
ENSTRUT00000007982	Kif2c	Kinesin-like protein KIF2C		Protein binding		−3.2
ENSTRUT00000013282	Lnx2	Ligand of Numb protein X2		Protein binding		−3.2
ENSTRUT00000005850	Crybb2	Beta-crystallin A2		Protein binding		−3.2
ENSTRUT00000003860	Edaradd	Ectodysplasin-A receptor-associated adapter protein		Protein binding		−3.1
ENSTRUT00000015819	Pbxip1	Pre-B-cell leukemia transcription factor-interacting protein 1		Transcription factor		−3.1
ENSTRUT00000011222	Serpinh1	Serpin H1		Protein binding		−3.1
ENSTRUT00000020096	Atp2b3	Plasma membrane calcium-transporting ATPase 3		Transporter activity		−3.1
ENSTRUT00000009874	Plxdc1	Plexin domain-containing protein 1		Unknown		−3.1
ENSTRUT00000047512	Suox	Sulfite oxidase, mitochondrial		Enzyme, cofactor		−3.1
ENSTRUT00000020028	finTRIM	Fish virus induced TRIM protein		Metal ion binding		−3.0
ENSTRUT00000041535	Pxn	Paxillin		Protein binding		−3.0
ENSTRUT00000033313	Nox5	T. rubripes NADPH oxidase 5 (BR000279.1)		Enzyme, cofactor		−3.0
ENSTRUT00000027204	Pacs2	Phosphofurin acidic cluster sorting protein 2		Unknown		−3.0
ENSTRUT00000044222	Tgfbrap1	Transforming growth factor-beta receptor-associated protein 1		Protein binding		−3.0
ENSTRUT00000027017	Hnrnpk	Heterogeneous nuclear ribonucleoprotein K		Transcription factor		−3.0
ENSTRUT00000043644	Hsp90b1	Heat shock protein 90kDa beta member 1		Protein binding		−3.0
ENSTRUT00000043157	Tle3	T. rubripes transducin-like enhancer protein 3 (AB236415.1)		Transcription factor		−3.0
ENSTRUT00000022207	Vwa1	Von Willebrand factor A domain-containing protein 1		Unknown		−3.0
ENSTRUT00000026592	Tacr3	Neuromedin-K receptor		Receptor activity		−3.0
ENSTRUT00000028610	Dach1	Dachshund homolog 1		Protein binding		−3.0
ENSTRUT00000011629	Gas2l3	GAS2-like protein 3		Protein binding		−3.0
ENSTRUT00000018505	Epha2	Ephrin type-A receptor 4 precursor		Receptor activity		−3.0

¹ FC is the average fold change of the TTX-administered (n = 5) compared to buffer-administered control group (n = 5).