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. 2009 May 26;27(21):3430–3436. doi: 10.1200/JCO.2008.18.4085

Fig 1.

Fig 1.

Topoisomerase II α copy number versus HER2 copy number. Topoisomerase IIα and HER2 copy number was determined using Vysis Triple Probe kit (HER2, TOP2A, CEP17). The topoisomerase IIα ratio was measured by counting the number of TOP2A signals/nucleus in a minimum of 20 nuclei over the number of CEP17 signals/nucleus in a minimum of 20 nuclei. The HER2 ratio was measured by counting the number of HER2 signals/nucleus in a minimum of 20 nuclei over the number of CEP17 signals/nucleus in a minimum of 20 nuclei. Topoisomerase IIα ratio (Y-axis) is plotted against HER2 ratio (X-axis) and the correlation coefficient calculated using SAS 9.1.