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Disease-free survival by cyclophosphamide, doxorubicin, and fluorouracil (CAF) dose in tumors with topoisomerase (topo) II α amplification, deletion and normal copy number. Kaplan-Meier estimates were calculated using SAS 9.1 for disease-free survival by CAF dose (low, moderate, high) for tumors with topo IIα amplification, topo IIα deletion and topo IIα diploid (normal) copy number. P = .15, interaction term for the three arms.
