Table 4.

Drug-Related Adverse Events

Adverse Event	All Patients (N = 174)				Patients With Imatinib-Resistant Disease (n = 161)				Imatinib-Intolerant Patients (n = 13)
	All Grades		Grade 3/4		All Grades		Grade 3/4		All Grades		Grade 3/4
	No.	%	No.	%	No.	%	No.	%	No.	%	No.	%
Nonhematologic events*
Diarrhea	90	52	13	8	81	50	11	7	9	69	2	15
Headache	51	29	1	< 1	49	30	1	< 1	2	15	0	0
Nausea	48	28	1	< 1	45	28	1	< 1	3	23	0	0
Pleural effusion	47	27	8	5	44	27	8	5	3	23	0	0
Fatigue	46	26	7	4	42	26	6	4	4	31	1	8
Pyrexia	42	24	7	4	38	24	6	4	4	31	1	8
Peripheral edema	39	22	1	< 1	35	22	1	< 1	4	31	0	0
Dyspnea	37	21	7	4	34	21	7	4	3	23	0	0
Rash	36	21	2	1	33	21	2	1	3	23	0	0
Vomiting	35	20	4	2	29	18	4	3	6	46	0	0
Anorexia	27	16	1	< 1	25	16	1	< 1	2	15	0	0
Asthenia	24	14	4	2	22	14	4	3	2	15	0	0
Petechiae	24	14	2	1	22	14	2	1	2	15	0	0
Arthralgia	22	13	0	0	22	14	0	0	0	0	0	0
Pain in extremity	21	12	0	0	20	12	0	0	1	8	0	0
Abdominal pain	19	11	0	0	17	11	0	0	2	15	0	0
Myalgia	20	12	1	< 1	19	12	1	< 1	1	8	0	0
Cough	18	10	1	< 1	18	11	1	< 1	0	0	0	0
Dizziness	18	10	0	0	17	11	0	0	1	8	0	0
Cytopenia
Thrombocytopenia	167	97	141	82	155	97	131	82	12	92	10	77
Neutropenia	159	92	131	76	146	91	118	74	13	100	13	100
Anemia	172	99	120	69	159	99	109	68	13	100	11	85
Leukocytopenia	152	88	102	59	140	88	91	57	12	92	11	85

^*Nonhematologic adverse events occurring with a frequency ≥ 10% are listed.