Table 2.

Selected differentially expressed genes utilizing an equine specific microarray following administration of an escalating dosing regimen (0.8 μg/kg, BID × 3 days; 1.6 μg/kg, BID × 3 days; 2.4 μg/kg, BID × 3 days; 3.2 μg/kg, BID for 21 days) to 6 exercised Thoroughbred research horses. For microarray analysis, baseline (pre-dose) transcript levels were compared to transcript levels on day 28

Gene symbol	Gene name	Fold change	P value (FDR corrected)
MYH2A	Myosin Heavy Chain 2A, skeletal muscle	−30.5	<0.001
MYH7	Myosin Heavy Chain 7, cardiac and skeletal	1.39	0.002
MYH8	Myosin Heavy Chain 8, skeletal muscle	1.86	0.014
MYH9	Myosin Heavy Chain 9, non-muscle	−2.60	0.001
MYH10	Myosin Heavy Chain 10, non-muscle	−1.31	0.028
MYH11	Myosin Heavy Chain 11, smooth muscle	−2.24	0.033
MYH15	Myosin Heavy Chain 15	2.10	<0.001
ADRB2	Adrenoreceptor, beta 2	−4.0	0.001
COL1A1	Collagen, type 1, alpha 1	−1.8	0.019
IL1A	Interleukin 1, alpha	3.42	<0.001
IL6	Interleukin 6	3.38	0.002
IL31RA	Interleukin 31, receptor A	2.77	<0.001
DSC2	Desmocollin 2	2.95	0.001
PMP22	Peripheral myelin protein 22	−2.5	<0.001
PMPCA	Peptidase alpha	−2.64	<0.001
KRTAP20-2	Keratin associate protein 20-2	7.32	<0.001