Table A1.

ISCL/EORTC Revised Staging System for MF/SS

Stage	T*	N†	M‡	B§
IA	1	0	0	0, 1
IB	2	0	0	0, 1
IIA	1, 2	1, 2	0	0, 1
IIB	3	0-2	0	0, 1
IIIA	4	0-2	0	0
IIIB	4	0-2	0	1
IVA1	1-4	0-2	0	2
IVA2	1-4	3	0	0-2
IVB	1-4	0-3	1	0-2

Abbreviations: EORTC, European Organisation for Research and Treatment of Cancer; ISCL, International Society for Cutaneous Lymphomas; MF, mycosis fungoides; SS, Sézary syndrome.

^*T1, patches or plaques covering < 10% of the body surface. Further stratified into T1a (patches only) and T1b (plaque ± patch); T2, patches or plaques ≥ 10% of the body surface. Further stratified into T2a (patches only) and T2b (plaque ± patch); T3, more than one tumor (≥ 1 cm); T4, erythroderma, which means involvement of more than 80% of skin.

^†B0, absence of significant blood involvement: < 5% of peripheral-blood lymphocytes are atypical (Sézary) cells; B0a, clone negative; B0b, clone positive. B1, low blood tumor burden: > 5% of peripheral-blood lymphocytes are atypical (Sézary) cells but does not meet the criteria of B2; B1a, clone negative; B1b, clone positive. B2, high blood tumor burden: > 1,000/L Sézary cells with positive clone.

^‡N0, no palpable lymphadenopathy or histologic evidence of mycosis fungoides. N1, clinically abnormal peripheral lymph nodes and histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. Further stratified into N1a (clone negative) and Nab (clone positive). N2, clinically abnormal peripheral lymph nodes and histopathology Dutch grade 2 or NCI LN3. Further stratified into N2a (clone negative) and N2b (clone positive). N3, clinically abnormal peripheral lymph nodes and histopathology Dutch grade 3 or 4 or NCI LN4 (clone positive or negative). Nx, clinically abnormal peripheral lymph nodes but no histologic confirmation.

^§M0, no visceral involvement; M1, histologically confirmed visceral involvement.