Fig. 6.

Effects of mechanical ventilation after PA or normal saline instillation on number of neutrophils and macrophages in BALF of WT and JNK1^−/− mice. a Mechanical ventilation after saline or 1 × 10⁶ CFU PA instillation induced a significant increase of neutrophils in BALF of WT mice but not in JNK1^−/− mice. n = 3-4/group. b The extent of neutrophil infiltration (arrowhead) and alveolus swelling (arrow) in the lungs were observed by hematoxylin and eosin staining. Mechanical ventilation after PA instillation induced significant parenchyma swelling and cell infiltration in WT mice as compared with JNK1^−/− mice. MV, mechanical ventilation for 3 h; PA, Pseudomonas aeruginosa. **P < 0.01, ***P < 0.001