FIG 4.

Survival of N. meningitidis group B strain H44/76 after 60 min of incubation with IgG1 or IgG3 anti-FHbp or anti-P1.16 PorA chimeric MAbs and 20% human complement. (A) (Left) The IgG1 anti-PorA MAb has greater bactericidal activity than the respective IgG3 anti-PorA MAb against H44/76-WT. The reverse is true for the anti-FHbp MAbs, where IgG3 JAR3 has greater activity then the respective IgG1 JAR3 (middle) and IgG3 MAb502 has greater activity than the respective IgG1 MAb502 (right). (B) The IgG1 JAR3 has greater activity than the IgG3 JAR3 against the H44/76-OE (FHbp) mutant; however, IgG3 MAb502 still had more activity than IgG1 MAb502.