Table 1.
GWAS information and SMR results for 28 complex traits and diseases
| Trait/Disease | N for quantitative traits or Ncases/Ncontrols | Number of genes (probes) GWS for the SMR test | Number of genes (probes) not rejected by the HEIDI test | Reference |
|---|---|---|---|---|
| Attention deficit and hyperactivity disorder (ADHD) | 2787/2635 | – | – | [22] |
| Alzheimer's disease (ALZ) | 17,008/37,154 | 7 (8) | 2 (2) | [23] |
| Autism spectrum disorder (ASD) | 13,088/16,664 | – | – | [24] |
| Bipolar disorder (BIP1) | 7481/9250 | 1 (1) | 1 (1) | [25] |
| Major depressive disorder (MDD) | 9240/9519 | – | – | [26] |
| Inflammatory bowel disease (IBD) | 12,882/21,770 | 37 (40) | 14 (14) | [19] |
| Crohn's disease (CD) | 5956/14,927 | 29 (33) | 11 (12) | [19] |
| Ulcerative colitis (UC) | 6968/20,464 | 17 (17) | 6 (6) | [19] |
| Coronary artery disease (CAD) | 60,801/123,504 | 9 (9) | 5 (5) | [27] |
| Diastolic blood pressure (DBP) | 69,395 | 5 (5) | – | [28] |
| Systolic blood pressure (SBP) | 69,395 | 4 (4) | – | [28] |
| High-density lipoproteins (HDL) | 93,561 | 38 (43) | 12 (13) | [29] |
| Low-density lipoproteins (LDL) | 89,138 | 28 (31) | 6 (7) | [29] |
| Total cholesterol (TC) | 93,845 | 40 (43) | 8 (9) | [29] |
| Triglycerides (TG) | 90,263 | 22 (25) | 2 (2) | [29] |
| Type-2 diabetes (T2D) | 12,171/56,862 | – | – | [30] |
| Fasting glucose (FGLUCOSE) | 38,422 | 4 (5) | – | [31] |
| Fasting insulin (FINSULIN) | 23,823 | – | – | [31] |
| Cigarettes per day (CIGPERDAY) | 38,181 | 2 (3) | 1 (2) | [32] |
| Ever smoked (EVERSMOKED) | 74,035 | – | – | [32] |
| College completion (COLLEGE) [33] | 95,427 | 1 (1) | 1 (1) | [33] |
| Education attainment (EDUYEARS) | 101,069 | 3 (3) | 3 (3) | [33] |
| Intelligence quotient (IQ) | 17,989 | – | – | [34] |
| Agreeableness (AGREE) | 17,375 | – | – | [35] |
| Conscientiousness (CONS) | 17,375 | – | – | [35] |
| Extraversion (EXTRAVERT) | 17,375 | – | – | [35] |
| Neuroticism (NEUROTIC) | 63,661 | – | – | [36, 37] |
| Openness (OPEN) | 17,375 | – | – | [35] |
| Total | 247 (271) | 71 (77) |
Probe: a specific DNA sequence designed on a gene expression array to capture a transcript