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SNS-032 plasma concentration-time profiles. Mean pharmacokinetic profiles for all dose cohorts from patients with multiple myeloma and chronic lymphocytic leukemia are shown. Filled circles, 15 mg/m2, n = 3; open circles, 22 mg/m2, n = 2; filled inverted triangles, 33 mg/m2, n = 8; open triangles, 50 mg/m2, n = 7; filled squares, 75 mg/m2, n = 10; open squares, 100 mg/m2, n = 2; solid line, concentration that inhibits 90%.
