Table 3.
All Grade 3 and 4 Toxicities Reported With SNS-032 Treatment
| Adverse Events | CLL (n = 19) |
MM (n = 18) |
||
|---|---|---|---|---|
| No. of Patients | % | No. of Patients | % | |
| No. of patients reporting toxicity | 14 | 74 | 14 | 78 |
| Hematologic | ||||
| Neutropenia | 3 | 16 | 7 | 39 |
| Anemia | 1 | 5 | 6 | 33 |
| Thrombocytopenia | 0 | 0 | 1 | 6 |
| Febrile neutropenia | 0 | 0 | 4 | 22 |
| Gastrointestinal/hepatic | ||||
| Abdominal pain | 2 | 11 | 0 | 0 |
| Diarrhea | 1 | 5 | 0 | 0 |
| Vomiting | 1 | 5 | 0 | 0 |
| Cholecystitis | 0 | 0 | 1 | 6 |
| Hyperbilirubinemia | 1 | 5 | 0 | 0 |
| Transaminitis (ALT/AST) | 2 | 11 | 0 | 0 |
| Renal/electrolyte abnormal | ||||
| Acute renal failure | 1 | 5 | 1 | 6 |
| Hypokalemia | 1 | 5 | 1 | 5 |
| Hypocalcemia | 1 | 5 | 0 | 0 |
| Hypercalcemia | 0 | 1 | 0 | |
| Hyperuricemia | 1 | 5 | 0 | 0 |
| Respiratory | ||||
| Hypoxia | 2 | 11 | 0 | 0 |
| Dyspnea | 1 | 5 | 0 | 0 |
| Lung infiltration | 1 | 5 | 0 | 0 |
| Cardiovascular | ||||
| Hypotension | 2 | 11 | 0 | 0 |
| Capillary leak syndrome | 1 | 5 | 0 | 0 |
| Nervous system | ||||
| Dizziness | 1 | 5 | 0 | 0 |
| Infection | ||||
| Pneumonia | 2 | 11 | 2 | 11 |
| Cellulitis | 0 | 1 | 6 | |
| Sepsis | 0 | 1 | 6 | |
| Streptococcal bacteremia | 0 | 1 | 6 | |
| Otitis media | 1 | 5 | 0 | 0 |
| Other | ||||
| Asthenia | 2 | 11 | 0 | 0 |
| Fatigue/weakness | 2 | 11 | 0 | 0 |
| Noncardiac chest pain | 1 | 5 | 0 | 0 |
| Dehydration | 1 | 5 | 0 | 0 |
| Tumor lysis syndrome | 4 | 21 | 0 | 0 |
| Hyperglycemia | 0 | 0 | 1 | 6 |
Abbreviations: CLL, chronic lymphocytic leukemia; MM, multiple myeloma.