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. Author manuscript; available in PMC: 2016 Aug 10.
Published in final edited form as: Lancet Diabetes Endocrinol. 2015 Jun 10;3(10):816–825. doi: 10.1016/S2213-8587(15)00225-9

Figure 5. Schematic representation of the various changes during critical illness.

Figure 5

The scheme is based on both experimental investigations and studies with people. The net result of altered tissue thyroid hormone metabolism could be beneficial or maladaptive, dependent on disease duration and severity. TH=thyroid hormone. T3=tri-iodothyronine. Solid lines represent a causal association. Dashed lines represent a probable effect.