Table 2.
Characteristics of BRCA1/2 Mutation Families
| Characteristic |
BRCA1 Families (n = 112) |
BRCA2 Families (n = 80) |
||
|---|---|---|---|---|
| Overall No. (%) | Per Family* Median No. (IQR) | Overall No. (%) | Per Family* Median No. (IQR) | |
| Family members | 2,255 (100) | 15 (10-28) | 1,359 (100) | 13 (10-19) |
| Females | 1,171 (51.9) | 7 (4-14) | 677 (49.8) | 7 (4-9) |
| Index patients | 97 (4.3) | 1 (1-1) | 66 (4.9) | 1 (1-1) |
| Females | 97 (100) | 1 (1-1) | 62 (93.9) | 1 (1-1) |
| Index carriers | 112 (5.0) | 1 (1-1) | 80 (5.9) | 1 (1-1) |
| Females | 111 (99.1) | 1 (1-1) | 73 (91.3) | 1 (1-1) |
| Mutation carriers | 511 (22.7) | 3 (2-6) | 318 (23.4) | 3 (2-5) |
| Untested relatives | 1,105 (49.0) | 7 (5-14) | 615 (45.3) | 6 (4-8) |
| Noncarriers | 639 (28.3) | 4 (2-8) | 426 (31.3) | 4 (2-7) |
| Female cancer† | ||||
| Female breast cancer | 257 (21.9) | 2 (1-3) | 158 (23.3) | 2 (1-2) |
| Ovarian cancer | 138 (11.8) | 2 (1-2) | 40 (5.9) | 0 (0-1) |
| Male breast cancer† | 2 (0.2) | 0 (0-0) | 7 (1.0) | 0 (0-0) |
Abbreviations: IQR, interquartile range; NA, not applicable.
*
Data are presented irrespective of the family size (ie, not weighted by family size).
†
Numbers and percentages per sex.