Table 1.
Patient Demographics and Clinicopathologic Characteristics
| Characteristic | No. (%) of Patients |
P (hereditary v nonhereditary)* | ||
|---|---|---|---|---|
| With Hereditary Syndrome (n = 67) | Without Hereditary Syndrome (n = 126) | Total (N = 193) | ||
| Mean (range) age at diagnosis, years | 28.8 (17-35) | 29.1 (12-35) | 29 (12-35) | NS |
| Female sex | 33 (49.2) | 68 (54.0) | 101 (52.3) | NS |
| Race/ethnicity | NS | |||
| White | 51 (76.1) | 94 (74.6) | 145 (75.1) | |
| Black | 5 (7.5) | 9 (7.1) | 14 (7.3) | |
| Hispanic | 8 (11.9) | 18 (14.3) | 26 (13.5) | |
| Asian | 3 (4.5) | 5 (4.0) | 8 (4.1) | |
| Colorectal cancer site | < .001 | |||
| Right colon | 15 (22.4) | 25 (19.8) | 40 (20.7) | |
| Left colon | 12 (17.9) | 46 (36.5) | 58 (30.0) | |
| Rectum | 29 (43.3) | 54 (42.9) | 83 (43.0) | |
| Not specified | 11 (16.4) | 1(0.8) | 12 (6.2) | |
| Tumor stage | < .001 | |||
| 0/Tis | 1 (1.5) | 1 (0.8) | 2 (1.0) | |
| I | 8 (11.9) | 7 (5.6) | 15 (7.8) | |
| II | 11 (16.4) | 8 (6.3) | 19 (9.8) | |
| III | 20 (29.9) | 38 (30.2) | 58 (30.1) | |
| IV | 19 (28.4) | 71 (56.3) | 90 (46.6) | |
| Unknown | 8 (11.9) | 1 (0.8) | 9 (4.7) | |
| Grade of differentiation | < .001 | |||
| Moderately differentiated | 45 (67.2) | 84 (66.7) | 129 (66.8) | |
| Poorly differentiated | 8 (11.9) | 39 (31.0) | 47 (24.4) | |
| Unknown | 14 (20.9) | 3 (2.4) | 17 (10.4) | |
| Signet ring cells | < .001 | |||
| Yes | 3 (4.5) | 18 (14.3) | 21 (10.9) | |
| No | 50 (74.6) | 108 (85.7) | 158 (81.9) | |
| Unknown | 14 (20.9) | 0 (0) | 14 (7.2) | |
| Met Amsterdam I/II criteria | 11 (16.4) | 1 (0.8) | 12 (6.2) | |
| Family history | < .001 | |||
| FDR with CRC | 19 (28.4) | 4 (3.2) | 23 (11.9) | < .001 |
| FDR with other cancer | 20 (29.9) | 30 (23.8) | 50 (25.9) | NS |
| SDR with CRC | 28 (41.8) | 33 (26.2) | 62 (32.1) | < .047 |
| SDR with other cancer | 35 (52.2) | 95 (75.4) | 130 (67.4) | .001 |
| Personal history of other cancer | 22 (32.8) | 13 (10.3) | 35 (18.1) | < .001 |
Abbreviations: CRC, colorectal cancer; FDR, first-degree relative; NS, not significant; SDR, second-degree relative.
*
All tests were two sided.