Table 3.

Age- and Stage-Adjusted Hazard Ratios for Tumor Recurrence

Characteristic	Hazard Ratio	95% CI	P
African American v white race	2.15	1.04 to 4.48	.04
African American v white race also adjusted for:*
MATH	2.11	1.03 to 4.34	.04
TP53 mutation	1.93	0.90 to 4.14	.09
PAM50 basal subtype	1.48	0.67 to 3.27	.33
TNBC	1.47	0.68 to 3.14	.32
PAM50 subtype	1.35	0.62 to 2.95	.45
Multivariable model	1.24	0.57 to 2.71	.59
MATH	1.01	0.99 to 1.03	.53
TP53 mutation	2.06	1.03 to 4.11	.04
PAM50 basal subtype	3.82	1.86 to 7.85	< .001
TNBC	3.86	1.84 to 8.12	< .001
PAM50 subtype
Luminal A	Referent	Referent	Referent
Luminal B	2.07	0.76 to 5.66	.16
HER2	1.31	0.32 to 5.33	.71
Basal-like†	4.84	1.91 to 12.26	.001
Normal-like	0.40	0.05 to 2.97	.37

NOTE. African Americans, n = 94; whites, n = 526; hazard ratio for tumor recurrence, n = 34.

Abbreviations: HER2, human epidermal growth factor receptor 2; MATH, mutant allele tumor heterogeneity; PAM50, 50-gene set predictor using predication analysis of microarray method; TNBC, triple-negative breast cancer.

^*Hazard ratio for tumor recurrence comparing African Americans with whites adjusted for age and stage, separately for MATH, TP53 mutation, basal v nonbasal PAM50 subtype, TNBC, PAM50 subtype (with indicator variables), or in multivariable model including all of these variables.

^†Hazard ratio comparing PAM50 basal subtype with PAM50 luminal A subtype.