Figure 3.

Effect of ROF or ROL administration, with or without FOR or SAL coadministration, on airway eosinophil count. Eosinophils in BAL fluid of saline-challenged (CTL) and VEH-treated Ova S/C PNMT-KO (solid bars) and WT mice (open bars). Groups of Ova S/C PNMT-KO (solid bars) and WT mice (open bars) were administered with different drug combinations as indicated. In these groups of mice, either (A) ROF (5 mg/kg) or (B) ROL (5 mg/kg) were administered once daily via oral gavage or coadministered with twice-daily FOR (5 μg/kg, intraperitoneally) or SAL (1.5 μg/kg, intraperitoneally) for 12 days. Differential counting of cells was done with Wright-Geimsa staining. Data represent the mean (±SEM) from n = 5–7 mice in each group. *P < 0.05 significance compared with respective PNMT-KO or WT CTL; ^#P < 0.05 significance compared with respective PNMT-KO or WT treatment groups in the absence of ROF or ROL.