. 2016 Aug;55(2):153–158. doi: 10.1165/rcmb.2016-0063PS

Table 1.

Overview of the Most Popular Murine Models of Obesity and Their Relative Metabolic Parameters

Mouse Model	Obesity (Wks until Obese)	Dyslipidemia	Hyperglycemia	Leptin “Resistance” (Mutant)
Diet-induced obesity	+++ (20–25)	++	+/−	++
CPE^fat/fat	++ (12–15)	+++	++	+
Db/db (ObRb^−/−)	+++ (6–8)	++	+++	(++)^*
Ob/ob (Leptin^−/−)	++ (8–10)	+	+/−	(+++)^†

“Obesity” is categorized by mouse weight at time of separation from age/sex-matched lean control mouse weight by 20 g. Adapted by permission from Reference 36.

No long form of leptin receptor expressed.

^{^†}

No leptin expressed.