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. 2016 May 23;2:16032. doi: 10.1038/cddiscovery.2016.32

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Copyright © 2016 Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Comparison of perioperative serum CRP levels and kinetics among three surgical groups. CRP is an acute-phase protein characterized by rapid onset and short half-time, and its level and kinetics can be monitored as a marker of inflammatory status in CD patients. CRP levels are measured at three different timepoints (preoperative, POD1, POD5) to evaluate the inflammatory system competence after surgery and to evaluate disease-specific abnormal responses when compared with two control groups of surgical patients. Group B (patients undergoing appendectomy; n=50) is considered as a clinical model for CRP production after infective stimulus. Group C (patients undergoing right colectomy; n=50) is considered as a clinical model for CRP response to surgical trauma. Comparison between three groups allows to identify differences in CRP levels after surgery at each timepoint (a–c) and to assess different kinetics in CRP response (d and e). Bars show mean±S.E.M.; one-way ANOVA test is used for comparison of groups.