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. 2016 May 23;2:16032. doi: 10.1038/cddiscovery.2016.32

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Copyright © 2016 Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Comparison of serum CRP perioperative levels (mean±S.E.M) in patients with and without endoscopic recurrence at 12 months. The study population has been divided into two subgroups according to the presence of endoscopic recurrence (Rutgeerts' score ≥2) at 12 months. Boxplots show differences between the two subgroups in serum CRP concentration for each determination timepoint (a–c) and its kinetics (d and e). The dotted line shows the calculated CRP cutoff used as a prognostic factor for endoscopic recurrence. Calculated CRP cutoffs seem to be able to discriminate between the two groups: patients developing recurrence show higher CRP levels and constantly above the given diagnostic threshold in each determination except for the preoperative one.