Table 1. Incidence and severity of liver microscopic findings.

Test article	Vehicle	TNF-α	Pevonedistat	Pevonedistat+TNF-α
Incidence (n=5)
Single-cell necrosis (periportal)	0	0	0	4
Neutrophilic infiltration (periportal)	0	0	0	4
Hepatocyte karyomegaly	0	0	4	5
Mean severity (Graded 0–4)
Single-cell necrosis (periportal)	0	0	0	1.4
Neutrophilic infiltration (periportal)	0	0	0	0.8
Hepatocyte karyomegaly	0	0	0.8	1.0

Five representative Sprague-Dawley rats were administered single doses of the indicated compounds; livers were analyzed at necropsy by histopathology. The incidence of microscopic findings and average severity, in brackets, of the findings are indicated. Findings were graded on a scale of 0 (absent), 1 (minimal), 2 (mild), 3 (moderate), or 4 (marked).