Table 1. Summary of the effect of HDACi on EMT transcription factors expression in epithelial- and mesenchymal-like cells.
|
PEO1 |
OVCA429 |
SKOV3 |
HEY |
|||||
|---|---|---|---|---|---|---|---|---|
| Fold change±S.E.M. | P-value | Fold change±S.E.M. | P-value | Fold change±S.E.M. | P-value | Fold change±S.E.M. | P-value | |
|
Mocetinostat (5 μM) | ||||||||
| SNAI1 | 17.837±0.32 | 0.06 | 46.32±2.20 | 0.01 | 11.80±0.01 | 6.85E-05 | 71.84±0.5 | 0.001 |
| SNAI2 | 7.4±0.79 | 0.03 | 2.83±0.17 | 0.02 | 0.72±0.07 | 0.10 | 8.46±0.73 | 0.03 |
| ZEB1 | 12.79±0.28 | 0.006 | 12.31±0.18 | 0.001 | 0.75±0.06 | 0.05 | 0.36±0.07 | 0.006 |
| ZEB2 | 20.70±4.88 | 0.07 | 6.02±0.69 | 0.04 | 1.54±0.25 | 0.13 | 0.35±0.05 | 0.02 |
| TWIST1 | 3.07±0.01 | 0.0002 | 2.73±0.10 | 0.016 | 0.72±0.03 | 0.01 | 0.78±0.07 | 0.08 |
| GRHL2 | 1.28±0.09 | 0.09 | 0.36±0.004 | 0.037 | 1.93±0.6 | 0.19 | 1.43±0.01 | 0.01 |
|
Entinostat (5 μM) | ||||||||
| SNAI1 | 8.52±0.01 | 1.3E-05 | 11.9±0.25 | 0.005 | 5.47±0.03 | 0.0001 | 31.71±0.39 | 0.002 |
| SNAI2 | 5.01±0.23 | 0.01 | 1.36±0.02 | 0.01 | 0.66±0.019 | 0.1 | 5.96±0.37 | 0.02 |
| ZEB1 | 9.63±0.15 | 0.002 | 5.18±0.31 | 0.018 | 0.75±0.03 | 0.01 | 0.34±0.01 | 0.001 |
| ZEB2 | 14.68±2.78 | 0.06 | 2.26±0.28 | 0.05 | 1.54±0.04 | 0.02 | 0.32±0.01 | 0.04 |
| TWIST1 | 2.54±0.05 | 0.009 | 1.38±0.05 | 0.03 | 0.83±0.08 | 0.14 | 0.61±0.003 | 0.047 |
| GRHL2 | 1.21±0.01 | 0.008 | 0.44±0.009 | 0.04 | 0.72±0.01 | 0.28 | 1.00±0.23 | 0.49 |
|
CI994 (5 μM) | ||||||||
| SNAI1 | 2.13±0.03 | 0.001 | 5.72±0.11 | 0.002 | 2.78±0.11 | 0.01 | 18.59±1.89 | 0.03 |
| SNAI2 | 1.14±0.12 | 0.22 | 1.16±0.03 | 0.03 | 0.67±0.01 | 0.1 | 3.82±0.20 | 0.02 |
| ZEB1 | 2.48±0.1 | 0.008 | 2.49±0.24 | 0.04 | 0.82±0.02 | 0.02 | 0.58±0.02 | 0.002 |
| ZEB2 | 4.35±0.80 | 0.07 | 1.13±0.25 | 0.35 | 1.76±0.003 | 0.0001 | 0.68±0.06 | 0.06 |
| TWIST1 | 1.04±0.02 | 0.17 | 1.09±0.09 | 0.04 | 0.87±0.02 | 0.02 | 0.70±0.01 | 0.05 |
| GRHL2 | 1.03±0.04 | 0.31 | 0.76±0.02 | 0.08 | 1.47±0.91 | 0.38 | 1.08±0.21 | 0.08 |