Figure 7.

Schematic diagram showing intricate network of cytokines and glycolysis regulating life (transformation) and death decisions of blebbishields. FasL+AZ58 is a weak signal leading to weaker degradation of c-IAP2 (red dotted line). The solid red lines show the events that lead to demise of blebbishields by MOMP, caspase-3 and caspase-9 activation, glycolytic shut-down, ATP depletion, and secondary necrosis. Black arrows indicate survival signals. Although z-DEVD-fmk rescues glycolysis, VEGFR2 expression, and many IRES targets, it does not rescue transformation from blebbishields as it targets c-Myc and N-Myc expression. Red boxes, key destructive signals. Green boxes, key survival signals.