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. 2015 Oct 19;1:15044. doi: 10.1038/cddiscovery.2015.44

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Copyright © 2015 Cell Death Differentiation Association

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Cell morphology of HCT116 cells is altered by the H1047R mutation in the p110α kinase domain of PI3K. (a) Cell morphology of HCT116 cells. Top panel: cell morphologies of live parental, WT and MUT HCT116 cells captured at a ×20 magnification. Bottom panel: confocal images parental, WT and MUT HCT116 cells captured at a ×63 magnification. Cells were fixed and stained for F-actin (green). Nuclei were stained with DAPI (blue). (b) Movement and morphology of live HCT116 WT (top) and MUT (bottom) cell at a ×40 magnification. Cells were transfected with Lifeact-GFP and cultured in a chambered cover glass dish for 24 h, and fluorescence and DIC images were acquired over 20 min.